Ebola Virus Disease: Updated Pathophysiology and Clinical Aspects
نویسندگان
چکیده
The aim of this article is to review and update the pathophysiological mechanisms and clinical aspects of the Ebola virus disease including the novel therapeutic measures. Ebola virus, a RNA virus, was discovered in 1976 as “ Zaire ebolavirus “ and currently is responsible for outbreak in the west Africa. The mucin-liked region of the Ebola virus envelope play a significant role in viral infection in non-human primates and humans through attachment of the membrane anchored C-type lectins rather than specific receptors. Both humoral and cellular immunities are responsible for the survival. Several novel chemotherapeutics are developed and progressive, such as ZMapp, PMOs, BCX-4430, AVI-602, T-705, TMK-Ebola, CMX-001, etc.Health education and counseling of the communities should be implemented, particularly, distance education to reduce the burden of the Ebola-virus-disease stigmatization. Nevertheless, strategic prevention of this virus is the most significant control measures.
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